FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Anti-inflammatory, anti-ulcerogenic, cimetidine, Dennettiatripetala, indomethacin, proximate composition
The proximate composition and the effect of Dennettiatripetala aqueous fruit extract on platelet aggregation and erythrocyte membrane stability were assessed, the effect of oral administration of the extract on indomethacin and ethanol in HCl induced ulcer were also investigated in Albino Wistarrats. Results indicated that the extract contains 43.69 13.00, 5.50, 13.91, 17.40 and 6.50 percent of carbohydrates, crude fibre, ash content, protein, moisture and fat respectively. The extract treatment reduced the viscosityof platelet aggregation hence of the blood and increased transmission of the solution. Treatment with the extract, significantly (p<0.05) inhibited indomethacin induced ulceration in a dose related manner but non-significantly (p>0.05) inhibited ethanol inHCl induced ulceration. The percentage inhibition of the extract at 200 mg/kg b.w was comparable to cimetidine. This is an indication that aqueous fruit extract of Dennettiatripetala has anti-inflammatory and anti-ulcerogenic effect.
AOAC 2007. Official Methods of Analysis. Association of Analytical Chemists. 15th edn. Washington DC, USA, pp. 1121-1180. Adedayo BC, Ohoh G & Akindahonsi AA 2010. Changes inthe total phenol content and antioxidant properties of pepper fruit (Dennettiatripetala) with ripening. African J. Food Success, 4(6): 403 – 409. Aiyeloja AA & Bello OA 2006. Ethno botanical herbs in Nigeria. A case study of Enugu State. Edu. Res. Rev., 1: 16-22. Block G, Jerson CD, Norkus EP, Dalvi TB, Wong LG, Mcmanus JF & Hudes ML 2007. Usage, pattern, health and nutritional status of long term multiple dietary supplement users: A cross section study. Nutr. J., 6: 30 – 41. Daniel EI & Clement ON 2008. Effect of ethaolic extract of Dennettiatripetala fruit on Hematological parameters in Albino Wistarrats. Nig. J. Phynol. Success, 23(1-2): 13-17. Donald RB 2007. Antioxidant activities of flavonoids. Department of Environmental and Molecular Toxicology. Oregon State University, Ph.D Thesis. Gafer MK & Itodo AU 2011. Constituents of leaves of Dennettiatripetala. J. Agric. & Food Chem., 10(3): 2007-2016. Hostetteman M 2009. Peptic ulcer.A guide for practicing physician. J. Pharmacol. Toxicol., 29(1): 11-26. Karau DD, Tachancodon T, Ilboudo D & Simore J 2011. Sub-saharan Robiaceae: A review of their traditional usage, phytochemistry and biological activity. Pak. J. Bio. Sciences, 14: 149-169. Ojogbane E, Musa AD &Nwodo OFC 2011. Anti-inflammatory effects of the aqueous extract of Cyphostemaglaucophilla leaves. NISEB J., 11(1): 67-73. Okwu DE, Mora FNI & Anan EM 2005. Isolation and characterization of phenanthrenic alkaloid Uvariopsine from Dennettiatripetela fruits. J. Med. & Aromatic Plant Science, 27: 496-498. Olajidi AT & Mike FO 2005. Outlines of Food Analysis. Donald Publisher, 4(12): 1440-144. Onmukka GI 2005. Food analysis and instrumentation: Theory and practice. Naphthalic Print, Surulere, Lagos Nigeria, pp. 219-230. Oyemitan IA 2006. Evaluation of Dennettiatripetala G. Baker (Annonaceae.) for central nervous system activities. Ile-ife Nigeria. Department of Pharmacology, ObafemiAwolowo University An M.Phil Thesis. Pamela CC, Richard AH & Denise RP 2005. Lippincotts Illustrated Reviews Biochemistry. 3rd ed., Lippincott Williams and Wilkins, Philadelphia, pp. 335-338. Timothy CO & Okere CO 2008. Effect of Dennetiatripetela seed intake on the intra ocular pressure (IOP) of Normotensive emmetropic Nigerian Igbos. JNOA, 14: 14-17.
